This Painting is based on' God descending on mount Sinai from the book of exodus in Bible.
And the Lord came down on Mount Sinai,.... In the above visible tokens of his presence and power; otherwise he is the incomprehensible Jehovah, that immense and omnipotent Being, who fills heaven and earth, and cannot be contained and circumscribed in either:
on the top of the mount; where the fire he descended in rested, and where the smoke and thick cloud were, as a token of his presence.